Pharmaceuticals
Inline pharmaceutical crystallization monitoring
Track crystal nucleation, growth, and morphology directly in the process.
The challenge
Crystallization defines critical product attributes, while periodic samples may miss nucleation, growth, agglomeration, and breakage.
Crystallization defines critical product attributes, while periodic samples may miss nucleation, growth, agglomeration, and breakage. Inline analysis follows these changes and supports endpoint detection.
Size, shape, and agglomeration
Particle distribution and endpoint
Granulation, pellets, and PAT strategy
Visual results
Crystals and distributions tracked throughout the operation.
From objects to data
Continuous information that reveals change.
Size and distribution
Count and population
Shape and morphology
Real-time trends
Technology and application
SOPAT for crystallization; Parsum for dry streams.
SOPAT images crystals in suspension and tracks size, shape, population, and time evolution. Parsum measures powders, granules, and pellets in dry processes, including the IPP 80-P.
Technical note: Regulated use requires method validation, qualification, data governance, and integration aligned with the user’s PAT strategy.
Technical questions
Frequently asked questions about this application.
Can crystallization be monitored in real time?
Yes. With a suitable configuration, SOPAT can track nucleation, growth, agglomeration, breakage, size, and morphology directly in the suspension.
How can crystallization endpoint be identified?
Population, size, and distribution trends can indicate stabilization or process change after validation with the actual product.
Which technology suits dry granulation?
Parsum targets powders, granules, and pellets in dry streams; configuration depends on the process.
Can the system support a PAT strategy?
It can provide real-time data for development, monitoring, and control, with validation and governance defined by the user.
Technology and application
Request a technical assessmentLet’s assess your process conditions.
Tell us the product, expected range, concentration, available point, and measurement objective.